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Rajiv Gandhi Centre For Biotechnology :: Autonomous Institutions :: Institutions :: Home
Rajiv Gandhi Centre For Biotechnology

RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY

THIRUVANANTHAPURAM 695 014

Phone: 0471-2347973, 2347975, 2341716, Fax: 0471 2349303, 2346333, 2348096

e-mail : info@rgcb.res.in, Website: www.rgcb.res.in

 

RGCB VISION

 

      To be an international hub of biotechnology, providing the right combination of research & development with the dedication, transparency and creativity of an academic research centre combined with the power of innovation, IPR driven programs and business transformation to deliver discoveries for India.

      Produce highly trained manpower.

 

click here for Flow Chart

 

Research PROGRAMS

 

TRANSLATIONAL CANCER RESEARCH

 

  • Molecular Epidemiology of Human Papilloma Virus (HPV) infection in India.
  • Molecular Modeling and Screening for anti-HPV compounds.
  • Nutrigenomics of Human Papilloma Virus associated tumorigenesis.
  • Search for tumor markers to detect early onset of breast cancer: proteomic profiling of breast disease detected in a community screening program.
  • Molecular pathogenesis of oral cancer in young adults without tobacco habits.

 

  • Biomarkers for malignant transformation of oral leukoplakia: comparative analysis of transformed and untransformed lesions in a 10 year follows up.
  • Double blind randomized clinical trial of oral curcumin in oral premalignancy and assessment of biomarkers for efficacy.
  • Clinical relevance of tumor stem cells in assessment of treatment outcome and minimal residual disease.

 

HUMAN MOLECULAR GENETICS

 

Genetics of complex medical disorders including

        Population Genetics

        Pharmacogenetics

        Immunogenetics

        Epigenetics

 

CHEMICAL BIOLOGY

        Development of biopolymer based control delivery systems for anti cancer drug delivery.

        New polymer matrices for peptide/protein synthesis

        New techniques in polypeptide synthesis

        Development of Peptide antimicrobials:

        Newer methods for Enzyme immobilization

 

 

 

 

 

MOLECULAR REPRODUCTION

 

  • Genes regulating meiotic switching in testis

 

  • Sperm proteomics

 

  • Superoxide generating machinery in spermatozoa

 

  • Reactive oxygen species at embryo implantation

 

  • Genomic/ proteomic signature patterns at embryo implantation

 

MYCOBACTERIA RESEARCH

  • Bioprospecting for anti tuberculosis compounds
  • Genomic profile and drug resistance in Mycobacterium tuberculosis
  • Repository of local M. tuberculosis isolates.
  • Interaction of Mycobacterium tuberculosis with macrophages.

 

 

 

 

 

 

CANCER BIOLOGY

 

 

  • Development of novel cell based assays for anti-cancer drug screening.

 

  • Bioprospecting for anti cancer molecules.

 

  • Development of markers for chemoresistance.

 

  • Chemosensitization using non-toxic plant derived compounds
  • Molecular mechanisms of anti cancer agents.

 

  • TGF b and NF-kB signaling pathways.

 

  • Chemopreventive role of curcumin against cigarette smoke induced lung carcinogenesis.

 

  • Role of microtubules in cell division.

 

  • Tubulin-microtubule system: study of the nucleation stage of      microtubule assembly by g tubulin complex and anti-cancer drugs.

 

 

  • Biology and drug discovery in BRCA 1 mutated cancers.
  • Plant derived selective estrogen receptor modulators (SERMS)

 

MOLECULAR VIROLOGY

 

        Immunopathogenesis of emerging viral diseases-Chikungunya and Dengue

        Biomarkers for better diagnostics for Chikungunya and Dengue

        Models to screen natural compounds for anti Chikungunya, Dengue and Hepatitis C virus activity.

 

CHOLERA AND ENVIRONMENTAL BIOLOGY

  • Search for biofilm inhibitors and quorum sensing in Vibrios.
  • Mechanisms of emerging antibiotic resistance patterns in environmental isolates of Vibrio cholerae.
  • Metagenomics for anti microbial agents and commercially important enzymes.

 

 

 

 

NEUROBIOLOGY

 

Understanding and Prevention of Neurological Diseases

 

  • Bioprospecting for anti-epileptic molecules.
  • Bioprospecting for neuroprotective molecules.
  • Stem cell mediated therapy for epilepsy.

 

 

Molecular Basis of Learning and Memory

 

  • Structural and functional analysis of CaMKII- NMDA receptor interaction.
  • Interaction of CaMKII with Caveolins and Polysialyl transferases.

 

Neural Stem Cell Biology

 

  • Transplantation of embryonic stem (ES) cells.
  • Development of a stem cell therapy strategy for glaucoma.

 

 

 

Plant biotechnology

Spices Biotechnology

 

            Gene prospecting and transgenics in black pepper and ginger

 

Biotechnological Intervention in High Potential Medicinal Plants

 

           

  • Metabolic engineering of terpenoid secondary metabolites
  • Gene bank development and DNA fingerprinting.
  • Genetic and pharmacological characterization of the medicinal rice Njavara.

 

BIOPROSPECTING AND MOLECULAR PHARMACOLOGY

        Hepatoprotective evaluation of selected medicinal plants obtained from traditional Indian medicine.

        Gastroprotective   property of C. halicacabum Linn.

 

SERVICES TO THE COMMUNITY

      DNA fingerprinting for civil and criminal justice systems.

      DNA barcoding for plants and animals.

      Life Science strengthening in schools through teaching, seminars and student projects.

      Regional Facility for Molecular Diagnostics providing molecular diagnostics for viral diseases (Dengue, Chikungunya, Hepatitis C, Drug resistant Hepatitis B), Cancer, Cardiovascular risk and genetic diseases.

 

 

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